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2013年10月16日 (水)

中枢神経系と免疫系の関係

> 神経回路の仕組みと免疫の仕組みには何か大きな連関性があると考えています。(41951北村さん)

例えば、副腎皮質刺激ホルモン放出因子(CRH)という物質が、神経系と免疫系を繋ぐ物質の一つとして知られているようです。

視床下部等で分泌されるCRHは、脳内の血流によって下垂体に運ばれ、副腎皮質刺激ホルモン(ACTH)を分泌させる働きをもっています。さらに、ACTHは副腎に運ばれ、ストレス抵抗性を増すステロイドホルモンの一種であると同時に強力な免疫抑制剤でもある副腎皮質ホルモン(コルチゾール)の生成を促進させます。

逆に、CRHの分泌ニューロンは免疫系細胞から分泌される伝達物質(コルチゾールもその一つ)の標的になっていて、交感神経系や血管を通じて、神経系と免疫系の間で相互フィードバックが行われています。

「うつ病」患者に見られる典型的な生理異常の一つに、このコルチゾールの分泌異常(過剰もしくは欠乏)があり、主に中枢神経系でのCRHの分泌制御異常が原因とされています。コルチゾール欠乏型のうつ病患者では、免疫亢進(=免疫の過剰反応)による慢性疲労や筋肉痛が見られ、逆に、免疫疾患である慢性関節リウマチ患者の2割は、ある段階でうつ病を発症するという報告があるそうです。

「心の病」と呼ばれるものが中枢神経系の異常で、「体の異常」の一つに免疫異常があるとしたら、この2つは上のような神経系―免疫系のホルモン伝達を通して相互に関連しているといえます。

外来情報の受容・認識・反応という過程、相互連絡が化学物質で行われているなど、神経系と免疫系はその機能的側面でも共通点が多く、案外近い起源を持っているのかも知れません。

田中素

« ウィルスと脳細胞の関係について | トップページ | 免疫系、神経系の分子の共通点 »

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Otherwise, I will send your site through tens of millions of sites that will lead to the blocking of your site for life and you will lose everything and your reputation as well.
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Hey. Soon your hosting account and your domain seibutu-no-rekishi.cocolog-nifty.com will be blocked forever, and you will receive tens of thousands of negative feedback from angry people.

Pay me 0.5 BTC until June 1, 2019.
Otherwise, you will get the reputation of a malicious spammer, your site seibutu-no-rekishi.cocolog-nifty.com will be blocked for life and you will be sued for insulting believers. I guarantee this to you.

My bitcoin wallet:19ckouUP2E22aJR5BPFdf7jP2oNXR3bezL

Here is a list of what you get if you don’t follow my requirements:
+ abuse spamhouse for aggressive web spam
+ tens of thousands of negative reviews about you and your website from angry people for aggressive web and email spam
+ lifetime blocking of your hosting account for aggressive web and email spam
+ lifetime blocking of your domain for aggressive web and email spam
+ Thousands of angry complaints from angry people will come to your mail and messengers for sending you a lot of spam
+ complete destruction of your reputation and loss of clients forever
+ for a full recovery from the damage you need tens of thousands of dollars

All of the above will result in blocking your domain and hosting account for life. The price of your peace of mind is 0.5 BTC.

Do you want this?

If you do not want the above problems, then before June 1, 2019, you need to send me 0.5 BTC to my Bitcoin wallet: 19ckouUP2E22aJR5BPFdf7jP2oNXR3bezL

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2. I’ll send messages to 19,000,000 email addresses and very intrusive advertisements for making money and offer a free iPhone with your website address seibutu-no-rekishi.cocolog-nifty.com and your contact details.
And then send out abusive messages with the address of your site.
3. I will do aggressive spam on blogs, forums and other sites (in my database there are 35 978 370 sites and 315 900 sites from which you will definitely get a huge amount of abuse) of your site seibutu-no-rekishi.cocolog-nifty.com.
After such spam, the spamhouse will turn its attention on you and after several abuses your host will be forced to block your account for life.
Your domain registrar will also block your domain permanently.

All of the above will result in blocking your domain and hosting account for life.
If you do not want to receive thousands of complaints from users and your hosting provider, then pay before June 1, 2019.
The price of your peace of mind is 0.5 BTC.
Otherwise, I will send your site through tens of millions of sites that will lead to the blocking of your site for life and you will lose everything and your reputation as well.
But get a reputation as a malicious spammer.

My bitcoin wallet:19ckouUP2E22aJR5BPFdf7jP2oNXR3bezL

Hey. Soon your hosting account and your domain seibutu-no-rekishi.cocolog-nifty.com will be blocked forever, and you will receive tens of thousands of negative feedback from angry people.

Pay me 0.5 BTC until June 1, 2019.
Otherwise, you will get the reputation of a malicious spammer, your site seibutu-no-rekishi.cocolog-nifty.com will be blocked for life and you will be sued for insulting believers. I guarantee this to you.

My bitcoin wallet:19ckouUP2E22aJR5BPFdf7jP2oNXR3bezL

Here is a list of what you get if you don’t follow my requirements:
+ abuse spamhouse for aggressive web spam
+ tens of thousands of negative reviews about you and your website from angry people for aggressive web and email spam
+ lifetime blocking of your hosting account for aggressive web and email spam
+ lifetime blocking of your domain for aggressive web and email spam
+ Thousands of angry complaints from angry people will come to your mail and messengers for sending you a lot of spam
+ complete destruction of your reputation and loss of clients forever
+ for a full recovery from the damage you need tens of thousands of dollars

All of the above will result in blocking your domain and hosting account for life. The price of your peace of mind is 0.5 BTC.

Do you want this?

If you do not want the above problems, then before June 1, 2019, you need to send me 0.5 BTC to my Bitcoin wallet: 19ckouUP2E22aJR5BPFdf7jP2oNXR3bezL

How do I do all this to get this result:
1. I will send messages to 33 000 000 sites with contact forms with offensive messages with the address of your site, that is, in this situation, you and the spammer and insult people.
And everyone will not care that it is not you.
2. I’ll send messages to 19,000,000 email addresses and very intrusive advertisements for making money and offer a free iPhone with your website address seibutu-no-rekishi.cocolog-nifty.com and your contact details.
And then send out abusive messages with the address of your site.
3. I will do aggressive spam on blogs, forums and other sites (in my database there are 35 978 370 sites and 315 900 sites from which you will definitely get a huge amount of abuse) of your site seibutu-no-rekishi.cocolog-nifty.com.
After such spam, the spamhouse will turn its attention on you and after several abuses your host will be forced to block your account for life.
Your domain registrar will also block your domain permanently.

All of the above will result in blocking your domain and hosting account for life.
If you do not want to receive thousands of complaints from users and your hosting provider, then pay before June 1, 2019.
The price of your peace of mind is 0.5 BTC.
Otherwise, I will send your site through tens of millions of sites that will lead to the blocking of your site for life and you will lose everything and your reputation as well.
But get a reputation as a malicious spammer.

My bitcoin wallet:19ckouUP2E22aJR5BPFdf7jP2oNXR3bezL

Hey. Soon your hosting account and your domain seibutu-no-rekishi.cocolog-nifty.com will be blocked forever, and you will receive tens of thousands of negative feedback from angry people.

Pay me 0.5 BTC until June 1, 2019.
Otherwise, you will get the reputation of a malicious spammer, your site seibutu-no-rekishi.cocolog-nifty.com will be blocked for life and you will be sued for insulting believers. I guarantee this to you.

My bitcoin wallet:19ckouUP2E22aJR5BPFdf7jP2oNXR3bezL

Here is a list of what you get if you don’t follow my requirements:
+ abuse spamhouse for aggressive web spam
+ tens of thousands of negative reviews about you and your website from angry people for aggressive web and email spam
+ lifetime blocking of your hosting account for aggressive web and email spam
+ lifetime blocking of your domain for aggressive web and email spam
+ Thousands of angry complaints from angry people will come to your mail and messengers for sending you a lot of spam
+ complete destruction of your reputation and loss of clients forever
+ for a full recovery from the damage you need tens of thousands of dollars

All of the above will result in blocking your domain and hosting account for life. The price of your peace of mind is 0.5 BTC.

Do you want this?

If you do not want the above problems, then before June 1, 2019, you need to send me 0.5 BTC to my Bitcoin wallet: 19ckouUP2E22aJR5BPFdf7jP2oNXR3bezL

How do I do all this to get this result:
1. I will send messages to 33 000 000 sites with contact forms with offensive messages with the address of your site, that is, in this situation, you and the spammer and insult people.
And everyone will not care that it is not you.
2. I’ll send messages to 19,000,000 email addresses and very intrusive advertisements for making money and offer a free iPhone with your website address seibutu-no-rekishi.cocolog-nifty.com and your contact details.
And then send out abusive messages with the address of your site.
3. I will do aggressive spam on blogs, forums and other sites (in my database there are 35 978 370 sites and 315 900 sites from which you will definitely get a huge amount of abuse) of your site seibutu-no-rekishi.cocolog-nifty.com.
After such spam, the spamhouse will turn its attention on you and after several abuses your host will be forced to block your account for life.
Your domain registrar will also block your domain permanently.

All of the above will result in blocking your domain and hosting account for life.
If you do not want to receive thousands of complaints from users and your hosting provider, then pay before June 1, 2019.
The price of your peace of mind is 0.5 BTC.
Otherwise, I will send your site through tens of millions of sites that will lead to the blocking of your site for life and you will lose everything and your reputation as well.
But get a reputation as a malicious spammer.

My bitcoin wallet:19ckouUP2E22aJR5BPFdf7jP2oNXR3bezL

Hey. Soon your hosting account and your domain seibutu-no-rekishi.cocolog-nifty.com will be blocked forever, and you will receive tens of thousands of negative feedback from angry people.

Pay me 0.5 BTC until June 1, 2019.
Otherwise, you will get the reputation of a malicious spammer, your site seibutu-no-rekishi.cocolog-nifty.com will be blocked for life and you will be sued for insulting believers. I guarantee this to you.

My bitcoin wallet:19ckouUP2E22aJR5BPFdf7jP2oNXR3bezL

Here is a list of what you get if you don’t follow my requirements:
+ abuse spamhouse for aggressive web spam
+ tens of thousands of negative reviews about you and your website from angry people for aggressive web and email spam
+ lifetime blocking of your hosting account for aggressive web and email spam
+ lifetime blocking of your domain for aggressive web and email spam
+ Thousands of angry complaints from angry people will come to your mail and messengers for sending you a lot of spam
+ complete destruction of your reputation and loss of clients forever
+ for a full recovery from the damage you need tens of thousands of dollars

All of the above will result in blocking your domain and hosting account for life. The price of your peace of mind is 0.5 BTC.

Do you want this?

If you do not want the above problems, then before June 1, 2019, you need to send me 0.5 BTC to my Bitcoin wallet: 19ckouUP2E22aJR5BPFdf7jP2oNXR3bezL

How do I do all this to get this result:
1. I will send messages to 33 000 000 sites with contact forms with offensive messages with the address of your site, that is, in this situation, you and the spammer and insult people.
And everyone will not care that it is not you.
2. I’ll send messages to 19,000,000 email addresses and very intrusive advertisements for making money and offer a free iPhone with your website address seibutu-no-rekishi.cocolog-nifty.com and your contact details.
And then send out abusive messages with the address of your site.
3. I will do aggressive spam on blogs, forums and other sites (in my database there are 35 978 370 sites and 315 900 sites from which you will definitely get a huge amount of abuse) of your site seibutu-no-rekishi.cocolog-nifty.com.
After such spam, the spamhouse will turn its attention on you and after several abuses your host will be forced to block your account for life.
Your domain registrar will also block your domain permanently.

All of the above will result in blocking your domain and hosting account for life.
If you do not want to receive thousands of complaints from users and your hosting provider, then pay before June 1, 2019.
The price of your peace of mind is 0.5 BTC.
Otherwise, I will send your site through tens of millions of sites that will lead to the blocking of your site for life and you will lose everything and your reputation as well.
But get a reputation as a malicious spammer.

My bitcoin wallet:19ckouUP2E22aJR5BPFdf7jP2oNXR3bezL

Hey. Soon your hosting account and your domain seibutu-no-rekishi.cocolog-nifty.com will be blocked forever, and you will receive tens of thousands of negative feedback from angry people.

Pay me 0.5 BTC until June 1, 2019.
Otherwise, you will get the reputation of a malicious spammer, your site seibutu-no-rekishi.cocolog-nifty.com will be blocked for life and you will be sued for insulting believers. I guarantee this to you.

My bitcoin wallet:19ckouUP2E22aJR5BPFdf7jP2oNXR3bezL

Here is a list of what you get if you don’t follow my requirements:
+ abuse spamhouse for aggressive web spam
+ tens of thousands of negative reviews about you and your website from angry people for aggressive web and email spam
+ lifetime blocking of your hosting account for aggressive web and email spam
+ lifetime blocking of your domain for aggressive web and email spam
+ Thousands of angry complaints from angry people will come to your mail and messengers for sending you a lot of spam
+ complete destruction of your reputation and loss of clients forever
+ for a full recovery from the damage you need tens of thousands of dollars

All of the above will result in blocking your domain and hosting account for life. The price of your peace of mind is 0.5 BTC.

Do you want this?

If you do not want the above problems, then before June 1, 2019, you need to send me 0.5 BTC to my Bitcoin wallet: 19ckouUP2E22aJR5BPFdf7jP2oNXR3bezL

How do I do all this to get this result:
1. I will send messages to 33 000 000 sites with contact forms with offensive messages with the address of your site, that is, in this situation, you and the spammer and insult people.
And everyone will not care that it is not you.
2. I’ll send messages to 19,000,000 email addresses and very intrusive advertisements for making money and offer a free iPhone with your website address seibutu-no-rekishi.cocolog-nifty.com and your contact details.
And then send out abusive messages with the address of your site.
3. I will do aggressive spam on blogs, forums and other sites (in my database there are 35 978 370 sites and 315 900 sites from which you will definitely get a huge amount of abuse) of your site seibutu-no-rekishi.cocolog-nifty.com.
After such spam, the spamhouse will turn its attention on you and after several abuses your host will be forced to block your account for life.
Your domain registrar will also block your domain permanently.

All of the above will result in blocking your domain and hosting account for life.
If you do not want to receive thousands of complaints from users and your hosting provider, then pay before June 1, 2019.
The price of your peace of mind is 0.5 BTC.
Otherwise, I will send your site through tens of millions of sites that will lead to the blocking of your site for life and you will lose everything and your reputation as well.
But get a reputation as a malicious spammer.

My bitcoin wallet:19ckouUP2E22aJR5BPFdf7jP2oNXR3bezL

Hey. Soon your hosting account and your domain seibutu-no-rekishi.cocolog-nifty.com will be blocked forever, and you will receive tens of thousands of negative feedback from angry people.

Pay me 0.5 BTC until June 1, 2019.
Otherwise, you will get the reputation of a malicious spammer, your site seibutu-no-rekishi.cocolog-nifty.com will be blocked for life and you will be sued for insulting believers. I guarantee this to you.

My bitcoin wallet:19ckouUP2E22aJR5BPFdf7jP2oNXR3bezL

Here is a list of what you get if you don’t follow my requirements:
+ abuse spamhouse for aggressive web spam
+ tens of thousands of negative reviews about you and your website from angry people for aggressive web and email spam
+ lifetime blocking of your hosting account for aggressive web and email spam
+ lifetime blocking of your domain for aggressive web and email spam
+ Thousands of angry complaints from angry people will come to your mail and messengers for sending you a lot of spam
+ complete destruction of your reputation and loss of clients forever
+ for a full recovery from the damage you need tens of thousands of dollars

All of the above will result in blocking your domain and hosting account for life. The price of your peace of mind is 0.5 BTC.

Do you want this?

If you do not want the above problems, then before June 1, 2019, you need to send me 0.5 BTC to my Bitcoin wallet: 19ckouUP2E22aJR5BPFdf7jP2oNXR3bezL

How do I do all this to get this result:
1. I will send messages to 33 000 000 sites with contact forms with offensive messages with the address of your site, that is, in this situation, you and the spammer and insult people.
And everyone will not care that it is not you.
2. I’ll send messages to 19,000,000 email addresses and very intrusive advertisements for making money and offer a free iPhone with your website address seibutu-no-rekishi.cocolog-nifty.com and your contact details.
And then send out abusive messages with the address of your site.
3. I will do aggressive spam on blogs, forums and other sites (in my database there are 35 978 370 sites and 315 900 sites from which you will definitely get a huge amount of abuse) of your site seibutu-no-rekishi.cocolog-nifty.com.
After such spam, the spamhouse will turn its attention on you and after several abuses your host will be forced to block your account for life.
Your domain registrar will also block your domain permanently.

All of the above will result in blocking your domain and hosting account for life.
If you do not want to receive thousands of complaints from users and your hosting provider, then pay before June 1, 2019.
The price of your peace of mind is 0.5 BTC.
Otherwise, I will send your site through tens of millions of sites that will lead to the blocking of your site for life and you will lose everything and your reputation as well.
But get a reputation as a malicious spammer.

My bitcoin wallet:19ckouUP2E22aJR5BPFdf7jP2oNXR3bezL

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